Wiswell TE, Baumgart S, Gannon CM, Spitzer AR. Neonatal meningitis caused by Escherichia coli in The Netherlands. Lumbar puncture frequency and cerebrospinal fluid analysis in the neonate. Philadelphia, PA: WB Saunder Co 2004, pp 945–948. Textbook of Pediatric Infectious Diseases. Obstet Gynecol 2002 99: 109–115.įeigin RD, Cherry JD, Demmler GJ, Kaplan SL. Effect of antenatal and postnatal corticosteroid therapy on weight gain and head circumference growth in the nursery. Thorp JA, Jones PG, Peabody JL, Knox E, Clark RH. Meningeal inflammation in neonatal Gram-negative bacteremia. Gram-negative enteric bacillary meningitis: a twenty-one-year experience. Unhanand M, Mustafa MM, McCracken Jr GH, Nelson JD. Reference values of normal cerebrospinal fluid composition in infants ages 0 to 8 weeks. J Pediatr 1976 88: 473–477.īonadio WA, Stanco L, Bruce R, Barry D, Smith D. Cerebrospinal fluid evaluation in neonates: comparison of high-risk infants with and without meningitis. To tap or not to tap: high likelihood of meningitis without sepsis among very low birth weight infants. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA et al. Diagnosis of neonatal meningitis: the lumbar puncture, the blood culture and CSF parameters. Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany K, Lenfesty R et al. Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment. Kanegaye JT, Soliemanzadeh P, Bradley JS. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. Increase of Enterobacter in neonatal sepsis: a twenty-two-year study. Hervas JA, Ballesteros F, Alomar A, Gil J, Benedi VJ, Alberti S. Adverse perinatal outcome and resistant Enterobacteriaceae after antibiotic usage for premature rupture of the membranes and group B streptococcus carriage. Serious bacterial infections in febrile infants younger than 90 days of age: the importance of ampicillin-resistant pathogens. Am J Obstet Gynecol 1998 179: 879–883.īyington CL, Rittichier KK, Bassett KE, Castillo H, Glasgow TS, Daly J et al. Potential consequences of widespread antepartal use of ampicillin. Analysis of predisposing factors and outcome compared with matched control subjects. Report of the task force on diagnosis and management of meningitis. Conclusion:Ĭompared to GPC meningitis, GNR meningitis was associated with several aspects of the clinical history and laboratory findings including older age of presentation, antepartum exposure to antibiotics, and elevated CSF white blood cell and red blood cell counts. After correcting for gestational age, there was no observed difference in mortality between infants infected with GNR or GPC. No difference was noted in either CSF protein or glucose levels. GNR meningitis diagnosed in the first 3 days of life was associated with antepartum antibiotic exposure. GNR meningitis was more often diagnosed after the third postnatal day and was associated with higher white blood cell and red blood cell counts. There were no differences in gestational age, birth weight, infant sex, race, or rate of Caesarean section. We identified 77 infants with GNR and 86 with GPC meningitis. CSF cultures positive with coagulase-negative staphylococci were excluded. We compared cerebrospinal fluid (CSF) parameters (white blood cell count, red blood cell count, glucose, and protein), demographics, and outcomes between infants with GNR and GPC meningitis. We evaluated lumbar punctures from neonates cared for at 150 neonatal intensive care units managed by the Pediatrix Medical Group Inc. We sought to compare laboratory and clinical parameters of GNR and GPC meningitis in a cohort of term and premature infants. Early identification of potential risk factors for Gram-negative rod (GNR) infections versus Gram-positive cocci (GPC) infection prior to obtaining final culture results is of value in order to appropriately guide expirical therapy. Neonatal meningitis is an illness with potentially devastating consequences.
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